Effect of Fluoride and a Standardized Pollen Extract on the Hepatic P-450 System in Rats
نویسندگان
چکیده
The influence of a standardized pollen extract (Cernitin) on the hepatic cytochrome P-450 system was studied in rats chronically exposed to an aerosol of ammonium fluoride. The content of cytochrome P-450 and cytochrome b5 and the activities of NADPH-cytochrome c reductase, aminophenazone N-demethylase, and aniline hydroxylase were determined. After 3 months the content of cytochrome b5 in the F-intoxicated rats was significantly reduced by 27%, and after 6 months the activity of NADPHcytochrome c reductase and aniline hydroxylase decreased significantly by 24 and 20%, respectively. Simultaneous oral administration of pollen extract exerted a protective effect by normalizing these parameters of the cytochrome P-450 system.
منابع مشابه
The effect of four weeks of resistance training and date pollen extract on gene expression of some of tight junction proteins of the spinal-blood barrier in male rats
Background & Aim: Changes in the expression of blood-spinal barrier proteins play an important role in the move and development of neuro-inflammatory responses. This study investigated the effect of four weeks of resistance training and date pollen extract on the expression of claudin-5 and connexin-43 proteins in male rats. Methods: 30 male Wistar rats randomly divided into 6 groups: Control;...
متن کاملProtective Effects of Hydroalcoholic Extract of Alcea rosea Aerial Parts on Hepatic Enzyme Dysfunction Induced by Cadmium Chloride in Adult Male Rats
Introduction: Cadmium chloride causes hepatic dysfunction. In the present study, the protective effects of hydroalcoholic extract of Alcea rosea aerial parts were investigated on the hepatic enzyme dysfunction induced by cadmium chloride in adult male rats. Method: In this experimental study, 54 adult male Wistar rats were divided into six groups of 9 as follows; control group, sham group 1 re...
متن کاملInvestigating the Safety of Bee Pollen on Performance, Oxidative Stress and Histopathological Changes in the Liver, Kidney and Pancreas of Rats
Objective: The therapeutic effects of bee pollen have been proven in various studies, but toxicity studies in this field are limited. Therefore, in this study the possible toxicity effects of hydroalcoholic extract of flower pollen on liver, kidney and pancreatic tissues of male rats was investigated. Methods: Fourteen male rats were divided into two groups of seven: the first group received 8...
متن کاملMelia Azedarach L. Fruit Extract Effect on Plasma Lipid Profile and Cardiac and Hepatic Functions of Diabetic Rats
Objective: There are controversial reports about biological effects of the Melia Azedarach Linn. (MA). In the present study, the effect of MA fruit extract on lipid profile, cardiac and hepatic functions of diabetic rats was investigated. Materials and Methods: Thirty male Wistar rats were divided into five groups. Group 1 as the control group, Group 2 as the diabetic group, Group 3 and 4 as t...
متن کاملThe effect of aqua-ethanolic extract of yellow horned poppy (Glaucium flavum Crantz) on serum activity of hepatic enzymes and insulin concentration in diabetic male rats induced by alloxan
Background: Glaucium flavum Crantz (Yellow Horned Poppy, YPH) is used to reduce complications of diabetes in Iranian folk medicine. This study was conducted to compare the effect of aqua-ethanolic extract of Yellow Horned Poppy and Glibenclamide on serum levels of AST, ALT, ALP and insulin in diabetic rats induced by alloxan. Materials and Methods: In this experimental study, 40 adult male Wist...
متن کامل